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OPEN LETTER TO THE MAYOR zoning

THE MAYOR CITY OF AREZZO
Mr. Giuseppe Fanfani

Arezzo, February 1, 2010 Dear Mr. Mayor



The Syndicate INARSIND , solicited from members, has organized this collection of signatures of Engineers, Architects and Surveyors residing and practicing in the town of Arezzo , to bring attention to his staff and all political forces, discomfort and dissatisfaction of professionals in order to form and substance of the planning rules recently adopted. The preliminary
Please keep in mind the time spent away from the year 2000, the date of initiation for the Structure Plan, to date, and to evaluate the urban plan that still has not concluded its process.
the crossing of the PS I know well the causes, largely outside the Administration that she directs, which have helped to expand the times, but this does not alter the fact that 10 years of waiting is too much for any city, most Arezzo reason that has long shown signs of great difficulty, also certified by recent national statistics.
And now, after all these years, reached the decisive phase, we discover a tool that, despite the huge amount of data is, paradoxically, gaps and redundancy in its legislation, inaccurate.

The basic idea of \u200b\u200bthe Regulations, namely the growth of the city within itself, and the strengthening of urban structure and social surroundings to get through a series of small public and private, is fully correct, and we choose appropriate to the current economic situation, which requires a modest amount of investment size.

But the project has not been able to return this idea and indeed, in large part, denies it:

• the incredible increase of economic burden, hardly tolerable even in a state of development, will go to passed on to the final price, ie the consumer, thereby to brake the start of each initiative;
• the increase in costs for new national laws, amplified by the Regulations, together with those new requirements of the Regulation itself will produce an abnormal rise production costs;
• errors, on the overall approach and detail of the discipline of capital existing building, making it unnecessarily punitive to the needs of citizens and allow very little improvement in their housing conditions.

are present in the plan quantity and quality of such "mistakes" on the actual reading of the destination of entire urban areas and buildings, and then on the weather, to create enormous economic problems to companies, individuals, traders, craftsmen, such errors should be eliminated as soon as possible, abandoning the interventionist spirit that guided the choices of uses, and encourages maximum flexibility on the changes to get the number of functions that culture planning a more skilled now considers essential for a full use of every part of the city.

We Arezzo professionals, however, we are also concerned about the difficulty of interpretation of rules bloated and contradictory, which will threaten any responsibility on our part also spoke for a very small amount. The simplification of legislation, often required by professional associations, public administration is a duty and a right for all citizens, including technicians. As you well know, Mr. Mayor, with no certainty of law is undermining the very foundations of the social contract that obliges everyone to respect the law, thereby pushing society to the arbitrary and illegal. The reading of texts and drawings cumbersome and lacks a consistent logical structure can only encourage uncertainty, vagueness and disparity of treatment between citizens and engineers and this is not acceptable.
These and many are the cases that could lead for example, that would take too long to enumerate the scope of this document, but instead become the subject of separate observations.

However, the plan is adopted and now we want to operate with a positive attitude and able to find a solution to:

• the city to have an easy way to quickly provide answers to certain individuals and call in motion, as we said, an economic process with small investments spread, and therefore to give priority to the "guidelines for the management of existing settlements, in accordance with the Regional Planning Act No. 1 / 2005, Article 55, paragraph 1 letter a.
• administration to work immediately after and within a fixed time, the "discipline of the transformations of the arrangement of settlements, infrastructure and construction of the territory, in accordance with the Regional Planning Act No. 1 / 2005, Article 55, paragraph 1 letter b.
• professionals to work with a reasonable regulatory certainty.

This will be possible only a radical revision of the text cut and inconsistent and wrong in form and substance and with knowledge of the gravity of the moment for the city's economy as a whole that requires quick and effective decisions.

We ask you, Mr. Mayor as the whole political class Arezzo, an assumption of responsibility appropriate to the current difficulties, that allows to make the best choices, though difficult, putting in the hands of every possible option on the method to follow, but bearing in mind the fact that the instrument adopted without deep-rooted changes, will be largely useless, it will become reliable source of litigation and administrative leave because of the city in a state of almost total suspension of all economic activity other than construction.

INARSIND AREZZO

The Board

GAVE THEIR MEMBERSHIP
THE FOLLOWING PROFESSIONALS:


Leonardo LAMBS Engineer
Fabrizio ANDREONI Architect
Chiara ANGIOLO Architect
Sara SILVER Architect
Massimo ARRIGHI Architect
Mario BALDINI Architect
Mauro BALDO Architect
Silvio BALDO Surveyor
Massimiliano Baqué Architect
Maurizio Barbagli Architect
Mauro BARBERI Surveyor
Architect Daniel BARELLI
Mario BARTOLOMMEO Architect
Marco Becuccio Engineer
Alessandro Belardino Surveyor
Claudio BENIGNI Surveyor
Paul BERTI Engineer
Carlo BIAGINI Engineer
Luca BIANCONI Surveyor
Antonio BIGI Architect
Andrea Bigliazzi Surveyor
Alessio cantle bag Surveyor
Barbara cantle bag Architect
Bruno STAMPS Engineer
Marino BARRELS Architect
Alessandro BOVI Architect
Piero BRACELETS Engineer
Francis Braconi Surveyor
Alessandro BRUNI Surveyor
Gabrio tope Surveyor
Caesar CANTUCCI Architect
Massimo CAPACCIO Surveyor
Fabio CAPS Engineer
Lucio CAPS Engineer
Gianluca Cardes Surveyor
Lorenzo DEAR Surveyor
Marco CARNESCIALI Engineer
Francesca CASES Ghiandai Surveyor
Massimiliano CASES Ghiandai Surveyor
Veronica CASES Ghiandai Architect
Giocondo CASINI Surveyor
Francis CECCARELLI Architect
Stefano Ceccatelli engineer
Alberto Ceccherelli Surveyor
Francis CERINO Surveyor
Aldo SLIPPERS Surveyor
Alessandro CINELLI Architect
John CITIZENS Architect
Alessandro CLEMENTE Surveyor
Maria Giovanna CLEMENTE Surveyor
Daniela CLERICI Engineer
Marcello Cornacchini Surveyor
Serena COURSES Surveyor
Alessandro COZZI Surveyor
Peter Cretella Engineer
Azelio CRULLI Architect
Stefano THE HOLY Architect
Mauro DENCH Architect
Fabrizio OF SANGRO Architect
Mauro OF SANGRO Surveyor
Alessandro DONATI Architect
Sara DONATI Engineer
Massimo Dragons Engineer
Massimo Droandi Architect
Henry Eustorgio Architect
Corrado EVANGELISTI Surveyor
David CHORUS Architect
Alessandro Faralli Engineer
FEI Alessandro Engineer
Fabio FERRINI Architect
George Fornasari Architect
Luca FRANCI Surveyor
Giuliana FRANGIPANI Architect
Andrea FRISCO Surveyor
George Frontani Engineer
Claudia GABBRIELLI Engineer
Alessandro Gaille Surveyor
Elena Gallai Architect
Patrick GALLI Surveyor
Rossano Gallorini Surveyor
Anadela Gamurrini Architect
Francis GAZZABIN Architect
Henry engineer Gennai Alessandro
Geppetto Surveyor
Giancarlo Geppetto Architect
Alessandro GHEZZI Engineer
Marco Ghiandai Surveyor
Elisa YELLOW Architect
Mario GIANI Surveyor
Silvia GIANI Surveyor
Simone Giannullo Engineer
Antonella GIORGESCHI
Architect Paolo GIUSTI Engineer
Paul GIUSTINA Engineer
Veronica GRANULES Architect
GRAZIANO Alessandro Surveyor
Roberto Grigiotti Surveyor
Sara Guadagnoli Architect
Umberto Guarnacci Architect
Fabio Guidelli Surveyor
Claudio INZITARI Engineer
Savio LALLETTI Surveyor
Mirko Latorraca Surveyor
Antonio LEONARDI Architect
Elisa LEONARDI Architect
Lucio LEONARDI Surveyor
Michele FREED Architect
Andrea SMOOTH Surveyor
Alfredo LISI Architect
Antonio LIVI Surveyor
Marco LIVI Surveyor
Francis Lovrenco Engineer
Roberto Luçon Architect
Nicola Mafucci Architect
Gabriele BRANDS Architect
Andrea Mariottini Surveyor
Fabio Mascarucci Architect
Mario MALE Architect
Luca MASETTI Surveyor
Pelagatti MAXIMUM Architect
Cristina Mazzeschi Architect
Valentina DECKS Surveyor
Alessandro MELIS Architect
Franco Mencaroni Architect
Romina Menchini Surveyor
Francis MEASURES Architect
Chiara Modestino Architect
Salvatore MONACA Architect
Monia Monin Surveyor
Massimo MORANDI Engineer
Scarton MORENA Surveyor
Simone MORI Engineer
Pier Paolo NENCIOLI Architect
Marta EYES Architect
Mauro Occhino Surveyor
Stefania PACI Architect
Claudio Paggetti Architect
Francesco Pagliai Engineer
Peter Pagliardini Architect
Eugenio SHOT Surveyor
Renato PANFOLI Engineer
Marco ALSO Surveyor
George PARIS Surveyor
Monia PARRONCELLI Surveyor
Desirè PASINI Architect
John Passuello Architect
John plumes Architect
Giulia Pierozzi Surveyor
Paul POLEZZI Architect
Remo POLEZZI Architect
Lisa POLLINI Architect
Gherardo dine Surveyor
Claudia SPRING Architect
Mauro Procino Architect
Erika RICCI Architect
Lucio Ricciarini Surveyor
Marta Ricciarini Surveyor
Nunzio RIMMAUDO Architect
Francis ROMAGNOLO Architect
ROMEO Andrea Surveyor
Ruben ROMUALDO Architect
Roberto ROSSI Engineer
John rocks Architect
Pier Lodovico rocks Arch-Ing.
Philip SALVADORI Engineer
SALVI Francesco Engineer
Loretta SALVI Architect
Riviera SALVINI Surveyor
Fabiano HURRY Surveyor
Morena Scarton Surveyor
Andrea Sciadini Architect
Alessandro SENNA Surveyor
Luciano Senserini Architect
Alessandro SERAFIERI Surveyor
Marco SERAFINI Architect
Pasquale Serbin Surveyor
Marcello SERBOLI Surveyor
Courses SERENA Surveyor
Mirko WILD THYME Architect
Andrea SESTINI Engineer
Roberto SEVERE - N ° 314 Architect
Roberto SEVERE - N ° 547
Architect Paul SISI Engineer
Emanuela spignolo Architect Daniel
TALOZZI Architect
Laura Tavant Architect
Leonardo Tavant Surveyor
Massimo Tavant Architect
Patrick ATTEMPT Architect
Stefano TIBERIO Engineer
Claudio DYED Architect
Nicoletta DYED Engineer
Enzo Tretola Architect
Joseph TORINO Surveyor
Micaela Valdambrino Architect
Emanuele VALENTINI Surveyor
Carlo VANNUCCI Architect
Osvaldo Venturini Surveyor
Roberto VERDELLO Architect
Joseph Vigliarolo Surveyor
Donatella VIVIANI Architect

Comments To Put In A Baby Shower Card

Mutation analysis of BRCA1 and BRCA2 is conducted to assess the predisposition genetics of the patient to the development of breast and ovarian cancers. The genes BRCA1 and BRCA2 genes are the main responsible of most cases of hereditary predisposition to these patologie.Una part of the breast and ovarian cancers are so-called sporadic that random mutations are acquired during the course of life, and are not transmitted to offspring. A large percentage of cancers can be hereditary. It is estimated that about 14% of breast cancers and 10% of ovarian cancers are caused by recurrent mutations in BRCA1 tumors and BRCA2.I hereditary breast and ovarian applicants are caused by mutations in the germ line that can be transmitted by both parents, both boys and girls, in an autosomal dominant, that children have a 50% chance of inheriting the genetic susceptibility to the development of those cancers. People who inherit a germline mutation have been designed with a copy of the mutated gene. However it should be stressed that these individuals do not inherit cancer, but only the predisposition to develop cancer. Not all people who are carriers of the mutation develop malignant disease, although these mutations greatly increase the risk of developing cancer, this does not develop until the normal copy of the corresponding gene is not subject to change throughout life. Since each person inherits two copies of the same gene, it must incur a mutational event in each copy to suppress the function of that gene, the acquisition of a new mutation can then directly cause the onset of cancer. RISK STATISTICS

breast cancer
Following extensive studies of families at risk, it was found that women who have inherited mutations in BRCA1 or BRCA2 genes are likely to develop breast cancer in 87% of cases , compared with a 10% chance of non-mutation carriers. The inherited mutations in these genes result in a significant increase in women's risk of developing breast cancer at an early age (before menopause), thus representing a characteristic feature of inherited susceptibility. Recent studies have in fact demonstrated that more than half of women with mutations in BRCA genes develop breast cancer before age 50, with an average age of diagnosis of cancer aged 41.
ovarian tumors
The risk of ovarian cancer in case of occurrence of mutations in one of two genes in question, however, is between 44-60%, compared with 1% probability of non-carriers. Events

genetic susceptibility testing is also very useful for those women who have already developed breast cancer because, if carriers of BRCA mutations, are high risk of developing a new breast cancer or ovarian cancer. For example, it was found that women with BRCA1 mutations who have had breast cancer, risk of developing a new tumor in 64% of cases. Percentages are provided similar risk for ovarian cancer.
risk of other cancers
Recent studies have reported that inherited mutations of BRCA1 or BRCA2 genes significantly increase the risk of prostate cancer in men and colon cancer in both sexes. The risk of prostate cancer was estimated to be 3-4 times higher than the general population in humans BRCA mutation carriers, with a cumulative risk of '8% while the risk of colon cancer was estimated to be 4-5 times higher in both women and man, with a cumulative risk of 6%. INTERPRETATION OF RESULTS

Genetic testing determines whether a person has or without mutations in BRCA1 or BRCA2.Un positive result means that you have identified one or more specific mutations, and therefore can be estimated in probabilistic terms the risk of developing cancer associated with that type of mutation. Not all women with mutations in BRCA1 or BRCA2 develop malignant disease, but the risk is high enough. Although the disease is rare for the male, a man who has the BRCA1 or BRCA2 mutations have a risk more to develop a cancer mammella.Un negative result means that no mutation was not found. However, it is important to note that a negative result does not mean that the patient has zero risk of developing breast or ovarian cancer, these women have the same cancer risk reported for the general population, this is because most of this kind of is expressed in sporadic cancers, for reasons still not well known.
FEATURES
BRCA1 and BRCA2 genes BRCA1 and BRCA2 tumor suppressor genes are located respectively on chromosome 17 and chromosome 13. In genetically predisposed persons, loss of function of tumor suppressor gene is due to events recurrent mutation at the level of that gene, resulting in the production of a protein anormale.Il BRCA1 gene contains 24 exons and has a size of about 5.6 Kb, while the BRCA2 gene comprises 27 exons and has a size of approximately 10 kb L ' analysis of hundreds of persons of different ethnic groups with a family history of breast or ovarian cancer showed the presence of more than 150 different mutations in this gene, most of which produce a protein tronca.Le recurrent mutations in this gene are the cause of most cases of hereditary breast and ovarian cancer.

ANALYSIS OF MUTATION Mutation analysis of the DNA is carried out initially operate a reaction enzymatic amplification of DNA, known as Polymerase Chain Reaction (PCR), which allows in vitro amplification of a specific region of the molecule, copying in various stages, to obtain millions of copie.In this manner is amplified the complete coding region and the intron region for each exon of the gene, then PCR products so obtained are sequenced through the use of an automatic sequencer in fluorescent technology. The sequence of each exon was confirmed by sequencing the opposite strand, and then is carried the 'Comparative analysis of two sequences with a reference sequence without BRCA mutations (wild type sequence) to inquire whether presence of mutation.
Summary information about the disease:
Frequency:
investigated
Gene: BRCA1, BRCA2

employed methods:
automated sequencing
Report: Technical Report

Informed consent: must

Prenatal Diagnosis:

Inheritance: autosomal dominant

Advice Genetic
necessary
Biological samples that you can run the test: blood samples in EDTA


2 ml 2 ug DNA

Federico Cesareo