More EPO, more memoriaIl result could lead to new therapeutic strategies for treating disorders of the nervous system that impairs cognitive
A drug used to increase blood production in both medical treatments and as a specialty sports doping seems to have a positive effect on memory of the user. This is the conclusion of a work published in the online open access journal BMC Biology, shows that also such as erythropoietin (EPO) are not to be related to effects on blood production armies but also a direct influence on neurons. The result, obtained by observing a group of patients with chronic renal failure treated with EPO, it could lead to new therapeutic strategies for treating disorders of the nervous system that decrease the cognitive abilities, such as schizophrenia, multiple sclerosis and Alzheimer's . These effects of EPO could be linked to the influence of the drug on the production of blood, "said Hannelore Ehrenreich, researcher at the Max-Planck-Institut who led the study," but have found receptors for EPO on nerve cells suggests that other mechanisms are involved. "For study the mechanisms of increased cognitive abilities induced by the EPO, the researchers also studied the effect of the substance on mice to test the effect of long-term. After the treatment period, mice that received EPO showed in some situations to have a better memory than the placebo group: the effect lasted up to three weeks and then disappear to quarta.Gli specific memory improvements were associated the functionality of the hippocampus, a brain region which oversees the memory and other processes cognitivi.Tale correlation is the result of the subsequent analysis of hippocampal tissue, finding that the EPO influence the neurons of this structure.
Federico Cesareo
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