Plasma Vs Lcd Robusness

type 1
They feature:-A hereditary predisposition to allergic diathesis which seem related Ir genes that control the immediate response to allergens ,-The production of antibodies called IgE antibodies or atopic reagin, which attach themselves to mast cells and basophils, and this 'was shown long ago' to-antibody reaction triggers that each new contact with the allergen free from the cytoplasm of mast cells vasoactive substances responsible for the anaphylactic response. Lesperimento of Praussnitz-Kustner is fundamental to understand the type of allergy I siglificato. Kustner had hypersensitivity 'to fish. Praussnitz withdraws 'blood and inoculating' a bit under the skin 'serum, in the same place 24 hours after inoculation' a few drops of an extract of the fish and saw a rash occur, but so was 'documented the possibility' that the antibodies passively transported by a person allergic to a healthy person these were fixed and reacted in situ with specific antigen. These antibodies, as defined in Article name "reagins", were not immediately identified because of their low concentration in the blood were the more 'later in time when they were recognized as belonging to the IgE which were greatly increased in the blood of allergic patients, especially after prolonged exposure to the allergen responsible for the disease. 'Cause you achieve the manifestations of allergy type I need to lay down the IgE to mast cells of the tissues concerned, these phenomena do not occur naturally on the contrary that is' first injecting the allergen and then the serum containing reagins .. The meeting between allergen and IgE causes the extrusion of metachromatic granules from mast cells with release of vasoactive substances responsible for inflammation and spasm of smooth muscle by histamine, serotonin, bradykinin, kallidin, prostaglandine.Dai Leukocyte diapedesis is rushed to liberate lysosomal enzymes responsible for fever and pyrogenic substances. The allergic shock, called anaphylactic shock, is the most 'severe manifestation of allergy type I. This is an event that occurs almost always fatal within minutes of administration of u-soluble antigen to a subject previously sensitized. Anaphylaxis occurs with alarms District: oculorinite to the airways in allergic asthma and allergic bronchial asthma in which the front door of the allergen and 'respiratory, skin allergies and hives in nell'edema of Quincke and nell'eczema in which the front door of the allergen and 'generally invasive. IMMUNO-ALLERGIC REACTIONS

TYPE OF 2ND

are related to the production of cytotoxic antibodies cytolytic p. These antibodies IgG and IgM antibodies which react with constituents or cell antigens or haptens with antibodies that are linked to these. The establishment of the antigen-antibody binding to the complex gives the ability 'to fix complement or cytolytic action leading to direct cytotoxic. mediated mechanisms or opposition of the cells that will subsequently be destroyed by macrophages in the spleen and liver. This type of immune reactions are carried out in accidents incompatibility 'ABO-Rh blood transfusion, and many in eristroblastosi fetal hemolytic anemia, leukopenia, thrombocytopenia that may be affected: -Exogenous allergens which bind to the cell surface as aptenievocando an antibody response, note the drugs most 'frequently implicated in this disease as quinine, the chidina, sulfonamides, the phenacetin, the piramidone the sedormid the metilitouracile , salts of gold. -From a structural modification of the cell membrane induced by an allergen that sets up, in my view, the terms' cause the cell loses some of its more individual characteristics becoming "not self" and as such evoking the production of autoantibodies by some viruses act to that effect. IMMUNO-ALLERGIC REACTIONS

OF TYPE 3 °.

are influenced by the production of antibodies Building type IgG and IgM which sometimes act in the mechanism of immune complexes as nell'esempoi more 'classical serum sickness eterologo.La injection of horse serum as in serum and tetanus antitoxin, determined within 8 - 11 days antibody production anti-cavalloe the expiration of this term are found in circulation is the antigen that the antibody. The combination causes the release of vasoactive souls and a consequent increase in permeability 'vascolare.Questi antigen-antibody complexes are located in the walls of small vasidove fix the complement with a concentration in the blood undergoes a parallel decrease thus forming' immune complex antigen + antibody + complement that recall the neutrophils which engulf them. This type of grade 3 was considered the basis for many diseases such as glomerulonephritis, some glomerulonephritis, rheumatic fever. Combined-immunoreactions in the pulmonary eosinophilic infiltration, in some syndromes of asthma and mocofiti nell'aspergillosi bronchopulmonary. -In some forms of reactions to medications and the notorious Lupus eritemetoso disseminated. -In combination with extrinsic allergic alveolitis and rheumatoid arthritis. IMMUNO-ALLERGIC REACTIONS

type 4

reactions include immunity 'cell-mediated delayed to ensure that T cells independently of the presence of antibodies solubili.Si is a frequent immune response in practice, which manifests itself in the course of many infectious diseases such as tuberculosis, brucellosis, listeriosis affects that I regret most of living in Africa, by the action of allergens such haptens as contact dermatitis. The best example for me and 'given by the intradermal tubercolina.Nel virgin subject of tuberculosis, the intradermal injection of tuberculin does not evoke any reaction, but after the first inoculation of the tubercolinadetermina tuberculosis infection in 24 hours the appearance of a' important local infiltration of T lymphocytes affected by recall. T lymphocytes are the protagonists of this reaction and operate a cytotoxic mechanism but also through the liberalization of soluble factors such linfotossici and other substances that act on macrophages and granulocytes.